NMDA(與learning的關係)

NMDA :

NMDA (N-methyl-D-aspartic acid) is an amino acid derivative acting as a specific antagonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors.(Agranoff, Bernard W.; Siegel, George J. (1999). Basic neurochemistry: molecular, cellular, and medical aspects. Philadelphia: Lippincott-Raven, p326. ISBN 0-397-51820-X.)

與learning的關係

Synaptic plasticity dependent on NMDA receptors is thought to underlie certain types of learning and receptors. It is known that NMDA receptor dependent LTP can be induced by applying a few trains of high-frequency stimuli to the connection between two neurons.

(Agranoff, Bernard W.; Siegel, George J. (1999). Basic neurochemistry: molecular, cellular, and medical aspects. Philadelphia: Lippincott-Raven, p326. ISBN 0-397-51820-X.)

*NMDA 受體與學習、記憶

NMDA 受體活化是導致神經細胞產生長效性增強 (long-term potentiation ; LTP) 的主要機制。在 1989 年時 Morris 等學者，發現 NMDA

受體拮抗劑 AP5 灌流老鼠海馬迴，會抑制 LTP 的產生，這顯示 LTP 產生需要 NMDA 受體的活化 (Morris, 1989)。在 1987 年時 Cotman 等學者，

於自體放射顯影實驗發現 NMDA 受體分佈在整個腦部及海馬迴(hippocampus)、阿控伯核 (nucleus accumbens)、紋狀體 (striatum )、大腦

皮質 (cortex) 和杏仁核 (amygdaloid nuclei) (Cotman 1987)。NMDA 及non-NMDA 受體的拮抗劑及致效劑對於實驗動物的活動能力、睡眠週

期、空間的辨識與學習、報償行為、厭惡與食慾引起的行為和制約行為的調控有關。

(http://library.ndmctsgh.edu.tw/ttsweb/piggy/ttsweb/Document/000001661/327004e/23.pdf)